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COURSE: Adaptative Methods in clinical Research

COURSE: Adaptative Methods in clinical Research
Prof. T. Jaki (U. Lancaster), Language: English, MORNING: 2-4 from 9.00 am to 1 pm, 5 from 9.00 am to 12 pm.


Adaptative Methods in clinical Research



Thomas Jaki,  PhD in Statistics  (2006) from the Univ. of South Caroline, M.S. in Statistics (2003) from the  Johanes Kepler Univ. Professor of Statistics in the  Lancaster Univ.  and director of the  Medical and Pharmaceutical Statistics Research Unit  in Lancaster. His research areas of interest are:  Design and analysis of clinical  trials, Early phase drug development, Personalized medicine and Biostatistics. 


July 2nd to 4th, from 9:00 to 13:00h, July 5th, from 9:00 to 12:00h

Course contents

Lectures are held using Powerpoint while Labs are a mixture of SAS practicals, discussions and illustrations.

Day 1

  1. Lecture 1 - Introduction
  2. Lecture 2 - Two-stage designs for normally distributed data
  3. Lab 1 - Two-stage designs for clinical trials

Day 2

  1. Lecture 3 - Sequential designs
  2. Lab 2 - Group sequential designs for clinical trials
  3. Lecture 4 - Sample size reviews
  4. Lab 3 - Design issues (Discussion session)

Day 3

  1. Lecture 5 - Multi-arm adaptive designs
  2. Lab 4 - Estimation after an adaptive design
  3. Lecture 6 - Bias and Selection 

Day 4

  1. Lecture 7 - Fully flexible adaptive designs                               
  2. Discussion and end


  • MESIO students: 70€/course
  • UPC & UB students: 120€/course
  • Students from other public catalan universities: 200€/course
  • Member of research groups and institutes linked to the UPC or the UB:  200 €/course
  • XXIX International Biometric Conference attendees, ISBC society members and Societat Catalana d'Estadísticamembers: 250€/course
  • External: 350€ first enrolled course and 300€ each additional course