Upcoming GRBIO seminars

Online. If you want to attend, please, contact grbio@grbio.eu

Learnings and future directions from a Multi-state models consulting project

Cirrhosis is a chronic liver disease characterised by fibrosis and scarring, ultimately leading to liver dysfunction. Cirrhosis advances through compensated and decompensated stages, with end-stage disease often necessitating liver transplantation or leading to death. Multi-state models have been proposed in the literature to investigate disease progression in cirrhosis. In this talk, we revisit the challenges encountered while applying a multi-state model in a consulting project on cirrhosis. Specifically, we discuss the impact of censoring patterns inherent in the collected data and the estimation of key measures of interest. We conclude by outlining future research directions, including testing strategies and sample size calculation for studies considering multi-state models.

Biosketch

Marta Bofill Roig is a Serra Húnter Fellow (tenure-track lecturer) at the Universitat Politècnica de Catalunya - BarcelonaTech (UPC). Marta graduated in Mathematics and earned a Master’s in Statistics and Operations Research. After obtaining her PhD in 2020, she worked as a postdoctoral researcher at the Medical University of Vienna. She joined the Department of Statistics and Operations Research at the UPC in September 2024 in her current position.